Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions

Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in the recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell t...

Full description

Saved in:
Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2022-12
Main Authors: Monville, Christelle, Goureau, Olivier, Ben M'Barek, Karim
Format: Article
Language:English
Subjects:
Life Sciences
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue
container_start_page
container_title Cold Spring Harbor perspectives in medicine
container_volume
creator Monville, Christelle
Goureau, Olivier
Ben M'Barek, Karim
description Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in the recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.
format article
fullrecord <record><control><sourceid>hal</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03932669v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_HAL_hal_03932669v1</sourcerecordid><originalsourceid>FETCH-hal_primary_oai_HAL_hal_03932669v13</originalsourceid><addsrcrecordid>eNqVi8sKgkAYhYcoSMp3mG0LQcdbtgsphFp0XcugvzoxzsjMWPT2afQCnc13-DhngiwSxMQJA49Mh-6FseMFhMyRrfXDHRJG0Tp2LVSdGmmkggK6ATgFzvEFOk4LaEEYfNdM1PjEe8U6aUZzNdB-d3qD016p0R2EfHEoa8BUlMO_pUyMv3MP2jAp9BLNKso12D8u0Gq_u6WZ01Ced4q1VL1zSVmebY_56Fw_8UkUJU_P_2f7AS_FTUI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions</title><source>Open Access: PubMed Central</source><creator>Monville, Christelle ; Goureau, Olivier ; Ben M'Barek, Karim</creator><creatorcontrib>Monville, Christelle ; Goureau, Olivier ; Ben M'Barek, Karim</creatorcontrib><description>Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in the recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.</description><identifier>ISSN: 2157-1422</identifier><identifier>EISSN: 2472-5412</identifier><language>eng</language><publisher>Cold Spring Harbor Laboratory Press</publisher><subject>Life Sciences</subject><ispartof>Cold Spring Harbor perspectives in medicine, 2022-12</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1256-5140 ; 0000-0002-2556-0325 ; 0000-0001-7730-9143 ; 0000-0003-1256-5140 ; 0000-0002-2556-0325 ; 0000-0001-7730-9143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885</link.rule.ids><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-03932669$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Monville, Christelle</creatorcontrib><creatorcontrib>Goureau, Olivier</creatorcontrib><creatorcontrib>Ben M'Barek, Karim</creatorcontrib><title>Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions</title><title>Cold Spring Harbor perspectives in medicine</title><description>Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in the recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.</description><subject>Life Sciences</subject><issn>2157-1422</issn><issn>2472-5412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqVi8sKgkAYhYcoSMp3mG0LQcdbtgsphFp0XcugvzoxzsjMWPT2afQCnc13-DhngiwSxMQJA49Mh-6FseMFhMyRrfXDHRJG0Tp2LVSdGmmkggK6ATgFzvEFOk4LaEEYfNdM1PjEe8U6aUZzNdB-d3qD016p0R2EfHEoa8BUlMO_pUyMv3MP2jAp9BLNKso12D8u0Gq_u6WZ01Ced4q1VL1zSVmebY_56Fw_8UkUJU_P_2f7AS_FTUI</recordid><startdate>20221212</startdate><enddate>20221212</enddate><creator>Monville, Christelle</creator><creator>Goureau, Olivier</creator><creator>Ben M'Barek, Karim</creator><general>Cold Spring Harbor Laboratory Press</general><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-1256-5140</orcidid><orcidid>https://orcid.org/0000-0002-2556-0325</orcidid><orcidid>https://orcid.org/0000-0001-7730-9143</orcidid><orcidid>https://orcid.org/0000-0003-1256-5140</orcidid><orcidid>https://orcid.org/0000-0002-2556-0325</orcidid><orcidid>https://orcid.org/0000-0001-7730-9143</orcidid></search><sort><creationdate>20221212</creationdate><title>Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions</title><author>Monville, Christelle ; Goureau, Olivier ; Ben M'Barek, Karim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-hal_primary_oai_HAL_hal_03932669v13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monville, Christelle</creatorcontrib><creatorcontrib>Goureau, Olivier</creatorcontrib><creatorcontrib>Ben M'Barek, Karim</creatorcontrib><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Cold Spring Harbor perspectives in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monville, Christelle</au><au>Goureau, Olivier</au><au>Ben M'Barek, Karim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions</atitle><jtitle>Cold Spring Harbor perspectives in medicine</jtitle><date>2022-12-12</date><risdate>2022</risdate><issn>2157-1422</issn><eissn>2472-5412</eissn><abstract>Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in the recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.</abstract><pub>Cold Spring Harbor Laboratory Press</pub><orcidid>https://orcid.org/0000-0003-1256-5140</orcidid><orcidid>https://orcid.org/0000-0002-2556-0325</orcidid><orcidid>https://orcid.org/0000-0001-7730-9143</orcidid><orcidid>https://orcid.org/0000-0003-1256-5140</orcidid><orcidid>https://orcid.org/0000-0002-2556-0325</orcidid><orcidid>https://orcid.org/0000-0001-7730-9143</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2157-1422
ispartof Cold Spring Harbor perspectives in medicine, 2022-12
issn 2157-1422
2472-5412
language eng
recordid cdi_hal_primary_oai_HAL_hal_03932669v1
source Open Access: PubMed Central
subjects Life Sciences
title Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A27%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-hal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Photoreceptor%20Cell%20Replacement%20Using%20Pluripotent%20Stem%20Cells:%20Current%20Knowledge%20and%20Remaining%20Questions&rft.jtitle=Cold%20Spring%20Harbor%20perspectives%20in%20medicine&rft.au=Monville,%20Christelle&rft.date=2022-12-12&rft.issn=2157-1422&rft.eissn=2472-5412&rft_id=info:doi/&rft_dat=%3Chal%3Eoai_HAL_hal_03932669v1%3C/hal%3E%3Cgrp_id%3Ecdi_FETCH-hal_primary_oai_HAL_hal_03932669v13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true