An updated version of the Madagascar periwinkle genome

The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat cancer worldwide. Here, we provide a new version of...

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Bibliographic Details
Published in:F1000 research 2022-12
Main Authors: Cuello, Clément, Stander, Emily Amor, Jansen, Hans, de Bernonville, Thomas Duge, Oudin, A., Birer-Williams, Caroline, Lanoue, Arnaud, Giglioli-Guivarc’h, Nathalie, Papon, Nicolas, Dirks, Ron, Jensen, Michael Krogh, O’connor, Sarah Ellen, Besseau, Sébastien, Courdavault, Vincent
Format: Article
Language:English
Subjects:
Genetics
Life Sciences
Plants genetics
Online Access:Get full text
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Summary:The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat cancer worldwide. Here, we provide a new version of the C. roseus genome sequence obtained through the combination of Oxford Nanopore Technologies long-reads and Illumina short-reads. This more contiguous assembly consists of 173 scaffolds with a total length of 581.128 Mb and an N50 of 12.241 Mb. Using publicly available RNAseq data, 21,061 protein coding genes were predicted and functionally annotated. A total of 42.87% of the genome was annotated as transposable elements, most of them being long-terminal repeats. Together with the increasing access to MIA-producing plant genomes, this updated version should ease evolutionary studies leading to a better understanding of MIA biosynthetic pathway evolution
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research