Mathematical Model and Numerical Simulation of Conductometric Biosensor of Urea

In this article, a mathematical model was developed to describe and optimize the configuration of the urea biosensor. The biosensor is based on interdigitated gold microelectrodes modified with a urease enzyme membrane. The model presented here focuses on the enzymatic reaction and/or diffusion phen...

Full description

Saved in:
Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2022-07, Vol.34 (7), p.1131-1140
Main Authors: Zouaoui, Fares, Zine, Nadia, Errachid, Abdelhamid, Jaffrezic‐Renault, Nicole
Format: Article
Language:English
Subjects:
Analytical chemistry
analytical performance
Chemical Sciences
Conductometry
modelling
urea
urease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this article, a mathematical model was developed to describe and optimize the configuration of the urea biosensor. The biosensor is based on interdigitated gold microelectrodes modified with a urease enzyme membrane. The model presented here focuses on the enzymatic reaction and/or diffusion phenomena that occur in the enzyme membrane and in the diffusion layer. Numerical resolution of differential equations was performed using the finite difference technique. The mathematical model was validated using experimental biosensor data. The responses of the biosensor to various conditions were simulated to guide experiments, improve analytical performance, and reduce development costs.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.202100610