Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

• Published in: Europace (London, England) England), 2019-05, Vol.21 (5), p.796-802
• Main Authors: Milman, Anat, Hochstadt, Aviram, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Conte, Giulio, Arbelo, Elena, Kamakura, Tsukasa, Aiba, Takeshi, Napolitano, Carlo, Giustetto, Carla, Denjoy, Isabelle, Juang, Jimmy J M, Maeda, Shingo, Takahashi, Yoshihide, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Jespersen, Camilla H, Wijeyeratne, Yanushi D, Champagne, Jean, Calo, Leonardo, Huang, Zhengrong, Mizusawa, Yuka, Postema, Pieter G, Brugada, Ramon, Wilde, Arthur A M, Yan, Gan-Xin, Behr, Elijah R, Tfelt-Hansen, Jacob, Hirao, Kenzo, Veltmann, Christian, Leenhardt, Antoine, Corrado, Domenico, Gaita, Fiorenzo, Priori, Silvia G, Kusano, Kengo F, Takagi, Masahiko, Delise, Pietro, Brugada, Josep, Brugada, Pedro, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard
• Format: Article
• Language: English
• Subjects: Life Sciences
• ISSN: 1099-5129; 1532-2092
• DOI: 10.1093/europace/euy301

Abstract Aims Data on predictors of time-to-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD’s are scarce. Methods and results SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-to-first appropriate ICD discharge regarding patients’ characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-to-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P