Pseudomonas aeruginosa and its multiple strategies to access iron

Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made environments. It is also a pathogen for plants, animals, and humans. As for almost all living organisms, iron is an essential nutrient for the growth of P. aeruginosa. The bacterium has evolved complex systems to acc...

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Bibliographic Details
Published in:Environmental microbiology 2023-04, Vol.25 (4), p.811-831
Main Authors: Schalk, Isabelle J., Perraud, Quentin
Format: Article
Language:English
Subjects:
Aerobactin
Bacteria
Biological Transport
Catecholamine
Catecholamines
Complex systems
Enterobactin
Ferrichrome - metabolism
Genomes
Heme
Homeostasis
Humans
Iron
Iron - metabolism
Life Sciences
Microbiology and Parasitology
Molecular modelling
Pathogens
Plant bacterial diseases
Pseudomonas aeruginosa
Pseudomonas aeruginosa - metabolism
Pyoverdines
Siderophores
Siderophores - metabolism
Survival
Uptake
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Summary:Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made environments. It is also a pathogen for plants, animals, and humans. As for almost all living organisms, iron is an essential nutrient for the growth of P. aeruginosa. The bacterium has evolved complex systems to access iron and maintain its homeostasis to survive in diverse natural and dynamic host environments. To access ferric iron, P. aeruginosa is able to produce two siderophores (pyoverdine and pyochelin), as well as use a variety of siderophores produced by other bacteria (mycobactins, enterobactin, ferrioxamine, ferrichrome, vibriobactin, aerobactin, rhizobactin and schizokinen). Furthermore, it can also use citrate, in addition to catecholamine neuromediators and plant‐derived mono catechols, as siderophores. The P. aeruginosa genome also encodes three heme‐uptake pathways (heme being an iron source) and one ferrous iron acquisition pathway. This review aims to summarize current knowledge concerning the molecular mechanisms involved in all the iron and heme acquisition strategies used by P. aeruginosa.
ISSN:1462-2912
1462-2920
DOI:10.1111/1462-2920.16328