Transverse Fluctuations Control the Assembly of Semiflexible Filaments

The kinetics of the assembly of semiflexible filaments through end-to-end annealing is key to the structure of the cytoskeleton, but is not understood. We analyze this problem through scaling theory and simulations, and uncover a regime where filaments' ends find each other through bending fluc...

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Published in:Physical review letters 2023-12, Vol.131 (22), p.228401-228401, Article 228401
Main Authors: Sorichetti, Valerio, Lenz, Martin
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - chemistry
Actins - chemistry
Condensed Matter
Cytoskeleton
Intermediate Filaments
Microtubules
Physics
Soft Condensed Matter
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description The kinetics of the assembly of semiflexible filaments through end-to-end annealing is key to the structure of the cytoskeleton, but is not understood. We analyze this problem through scaling theory and simulations, and uncover a regime where filaments' ends find each other through bending fluctuations without the need for the whole filament to diffuse. This results in a very substantial speedup of assembly in physiological regimes, and could help with understanding the dynamics of actin and intermediate filaments in biological processes such as wound healing and cell division.
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subjects Actin Cytoskeleton - chemistry
Actins - chemistry
Condensed Matter
Cytoskeleton
Intermediate Filaments
Microtubules
Physics
Soft Condensed Matter
title Transverse Fluctuations Control the Assembly of Semiflexible Filaments
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