Chronic hepatitis E: Advancing research and patient care

The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis. However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly changed our understanding of this pathogen. We have now begun to understand that specific HEV genotypes can cause ch...

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Bibliographic Details
Published in:Journal of hepatology 2022-10, Vol.77 (4), p.1109-1123
Main Authors: Ma, Zhongren, de Man, Robert A., Kamar, Nassim, Pan, Qiuwei
Format: Article
Language:English
Subjects:
Chronic HEV infection
epidemiology
experimental models
Human health and pathology
Life Sciences
pathophysiology
prevention
treatment
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Summary:The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis. However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly changed our understanding of this pathogen. We have now begun to understand that specific HEV genotypes can cause chronic infection in certain immunocompromised populations. Over the past decade, dedicated clinical and experimental research has substantiated knowledge on the epidemiology, transmission routes, pathophysiological mechanisms, diagnosis, clinical features and treatment of chronic HEV infection. Nevertheless, many gaps and major challenges remain, particularly regarding the translation of knowledge into disease prevention and improvement of clinical outcomes. This article aims to highlight the latest developments in the understanding and management of chronic hepatitis E. More importantly, we attempt to identify major knowledge gaps and discuss strategies for further advancing both research and patient care.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2022.05.006