Maladie de Vogt–Koyanagi–Harada : regards croisés de l’ophtalmologiste et de l’interniste

Vogt-Koyanagi-Harada disease is due to an autoimmune reaction directed against melanocytes from the uvea, meninges, inner ear and the teguments which affects mainly colored populations with a female predominance. The disease starts with a brutal visual acuity loss due to diffuse acute choroiditis an...

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Bibliographic Details
Published in:La revue de medecine interne 2022-12, Vol.43, p.A289-A292
Main Authors: Roumieu, V., Stolowy, Natacha, Toback, D., Kaplanski, G.
Format: Article
Language:English
Subjects:
Life Sciences
Online Access:Get full text
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Summary:Vogt-Koyanagi-Harada disease is due to an autoimmune reaction directed against melanocytes from the uvea, meninges, inner ear and the teguments which affects mainly colored populations with a female predominance. The disease starts with a brutal visual acuity loss due to diffuse acute choroiditis and retinal serous detachments, followed by a chronic phase characterized by recurrent bouts of anterior granulomatous uveitis, sub-clinical choroiditis and a poor visual prognosis. At this stage, typical skin symptoms such as vitiligo, poliosis or alopecia may be observed. Indocyanine green angiography and Enhanced Depth Imaging-OCT are very useful for the diagnosis and the follow-up. The goal of the treatment is to control the initial acute choroidal inflammation using aggressive treatment with steroids and immunosuppressive drugs, in order to completely heal the choroiditis and to prevent chronic complications.
ISSN:0248-8663
1768-3122
DOI:10.1016/j.revmed.2022.10.007