Sensitivity of Single-Molecule Array Assays for Detection of Clostridium difficile Toxins in Comparison to Conventional Laboratory Testing Algorithms

Guidelines recommend the use of an algorithm for the laboratory diagnosis of Clostridium difficile infection (CDI). Enzyme immunoassays (EIAs) detecting C. difficile toxins cannot be used as standalone tests due to suboptimal sensitivity, and molecular tests suffer from nonspecificity by detecting c...

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Published in:Journal of clinical microbiology 2018-08, Vol.56 (8), p.34-38
Main Authors: Schiavone, Marco, Gasperetti, Alessio, Laredo, Mikael, Breitenstein, Alexander, Vogler, Julia, Palmisano, Pietro, Gulletta, Simone, Pignalberi, Carlo, Lavalle, Carlo, Pisanò, Ennio, Ricciardi, Danilo, Curnis, Antonio, Dello Russo, Antonio, Tondo, Claudio, Badenco, Nicolas, Di Biase, Luigi, Kuschyk, Jürgen, Biffi, Mauro, Tilz, Roland, Forleo, Giovanni Battista, Schiavone, M., Gasperetti, A., Arosio, R., Ruggiero, D., Viecca, M., Forleo, G.B., Ziacchi, M., Diemberger, I., Angeletti, A., Biffi, M., Fierro, N., Gulletta, S., Della Bella, P., Tondo, C., Mitacchione, G., Curnis, A., Compagnucci, P., Casella, M., Dello Russo, A., Santini, L., Pignalberi, C., Piro, A., Lavalle, C., Picarelli, F., Ricciardi, D., Bressi, E., Calò, L., Montemerlo, E., Rovaris, G., de Bonis, S., Bisignani, A., Bisignani, G., Russo, G., Pisanò, E., Palmisano, P., Guarracini, F., Vitali, F., Bertini, M., Vogler, J., Fink, T., Tilz, R., Fastenrath, F., Kuschyk, J., Kaiser, L., Hakmi, S., Laredo, M., Waintraub, X, Gandjbakhch, E., Badenco, N., Breitenstein, A., Saguner, A.M., Di Biase, L.
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Language:English
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Life Sciences
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Summary:Guidelines recommend the use of an algorithm for the laboratory diagnosis of Clostridium difficile infection (CDI). Enzyme immunoassays (EIAs) detecting C. difficile toxins cannot be used as standalone tests due to suboptimal sensitivity, and molecular tests suffer from nonspecificity by detecting colonization.
ISSN:0095-1137
DOI:10.1161/CIRCEP.122.011404