Specific Follicular Helper T Cell Signature in Takayasu Arteritis

Our aim was to compare transcriptome and phenotype profiles of CD4+ T cells and CD19+ B cells in patients with Takayasu arteritis (TAK), patients with giant cell arteritis (GCA), and healthy donors.

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Bibliographic Details
Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-02, Vol.73 (7), p.1233-1243
Main Authors: Desbois, A C, Régnier, P., Quiniou, V., Lejoncour, A., Maciejewski-Duval, A., Comarmond, C., Vallet, H., Rosenzwag, M., Darrasse-Jèze, G., Derian, N., Pouchot, J., Samson, M., Bienvenu, B., Fouret, P., Koskas, F., Garrido, M., Sène, D., Bruneval, P., Cacoub, P., Klatzmann, D., Saadoun, D.
Format: Article
Language:English
Subjects:
Adaptive immunology
Adult
Aged
Aged, 80 and over
Antigens, CD19
Antigens, CD20
Aorta
B-Lymphocytes
Cardiology and cardiovascular system
CD4-Positive T-Lymphocytes
Cell Proliferation
Female
Gene Expression Profiling
Giant Cell Arteritis
Human health and pathology
Humans
Immunoglobulin G
Immunologic Memory
Immunology
Immunophenotyping
Janus Kinase Inhibitors
Life Sciences
Male
Middle Aged
Nitriles
Programmed Cell Death 1 Receptor
Pyrazoles
Pyrimidines
Receptors, Antigen, T-Cell, alpha-beta
Receptors, CXCR5
T Follicular Helper Cells
Takayasu Arteritis
Tertiary Lymphoid Structures
Transcriptome
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Description
Summary:Our aim was to compare transcriptome and phenotype profiles of CD4+ T cells and CD19+ B cells in patients with Takayasu arteritis (TAK), patients with giant cell arteritis (GCA), and healthy donors.
ISSN:2326-5205
2326-5191
DOI:10.1002/art.41672