Design of fluorescently tagged poly(alkyl cyanoacrylate) nanoparticles for human brain endothelial cell imaging

Rhodamine B-tagged poly(alkyl cyanoacrylate) amphiphilic copolymers have been synthesised, characterised and successfully used to prepare fluorescent nanoparticles for human brain endothelial cell imaging, allowing their uptake and intracellular trafficking to be finely observed.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (15), p.2602-2604
Main Authors: Brambilla, Davide, Nicolas, Julien, Le Droumaguet, Benjamin, Andrieux, Karine, Marsaud, Véronique, Couraud, Pierre-Olivier, Couvreur, Patrick
Format: Article
Language:English
Subjects:
Brain - cytology
Cell Line
Cyanoacrylates - chemistry
Endothelial Cells - cytology
Fluorescent Dyes - chemistry
Galenic pharmacology
Humans
Life Sciences
Microscopy, Confocal
Nanoparticles - chemistry
Particle Size
Pharmaceutical sciences
Polymers - chemical synthesis
Polymers - chemistry
Rhodamines - chemistry
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Description
Summary:Rhodamine B-tagged poly(alkyl cyanoacrylate) amphiphilic copolymers have been synthesised, characterised and successfully used to prepare fluorescent nanoparticles for human brain endothelial cell imaging, allowing their uptake and intracellular trafficking to be finely observed.
ISSN:1359-7345
1364-548X
DOI:10.1039/b924028d