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Leptin: cutting the fat off the bone
Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action. Recently, Florent Elefteriou and colleagues (Endocrin...
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| Published in: | The Lancet (British edition) 2003-11, Vol.362 (9395), p.1572-1574 |
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| creator | Cock, Terrie-Anne Auwerx, Johan |
| description | Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action.
Recently, Florent Elefteriou and colleagues (Endocrinology 2003; 144: 3842-47) found that hypothalamic neurons control bone mass. These researchers used monosodium glutamate to obliterate neurons in the arcuate nucleus. Previously, this group (Cell 2002; 101: 305-17) had shown that leptin inhibits bone formation by modulating the sympathetic nervous system. Although leptin influences both energy balance and bone mass by acting on the hypothalamus, the two processes involve different proteins and neurons. WHERE NEXT? Leptin has antiosteogenic activity in mice, mediated by hypothalamic nervous pathways and the sympathetic nervous system. Yet some human studies dispute leptin's antiosteogenic role. Large clinical studies are necessary to consolidate leptin's role in the physiology of human bone. In mice the beta blocker propranolol, a widely used drug with no major deleterious effects, significantly increases bone formation and bone mass without affecting bodyweight, a finding that may provide novel opportunities to design efficient bone-forming drugs for human beings. |
| doi_str_mv | 10.1016/S0140-6736(03)14747-2 |
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Recently, Florent Elefteriou and colleagues (Endocrinology 2003; 144: 3842-47) found that hypothalamic neurons control bone mass. These researchers used monosodium glutamate to obliterate neurons in the arcuate nucleus. Previously, this group (Cell 2002; 101: 305-17) had shown that leptin inhibits bone formation by modulating the sympathetic nervous system. Although leptin influences both energy balance and bone mass by acting on the hypothalamus, the two processes involve different proteins and neurons. WHERE NEXT? Leptin has antiosteogenic activity in mice, mediated by hypothalamic nervous pathways and the sympathetic nervous system. Yet some human studies dispute leptin's antiosteogenic role. Large clinical studies are necessary to consolidate leptin's role in the physiology of human bone. In mice the beta blocker propranolol, a widely used drug with no major deleterious effects, significantly increases bone formation and bone mass without affecting bodyweight, a finding that may provide novel opportunities to design efficient bone-forming drugs for human beings.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(03)14747-2</identifier><identifier>PMID: 14615115</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Animals ; Anorexia ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Biomedical materials ; Blood pressure ; Bone Density - drug effects ; Bone Density - physiology ; Bones ; Brain stem ; Cardiovascular diseases ; Cocaine ; Congenital diseases ; Deletion ; Density ; Disease control ; Energy ; Energy balance ; Energy Metabolism - drug effects ; Energy Metabolism - physiology ; Food ; Genetics ; Gold ; Hormones ; Humans ; Hypothalamus - drug effects ; Hypothalamus - physiology ; In vivo methods and tests ; Investigative techniques, diagnostic techniques (general aspects) ; Leptin ; Leptin - pharmacology ; Leptin - physiology ; Life Sciences ; Maintenance ; Medical sciences ; Metabolic diseases ; Mice ; Mice, Obese ; Nervous system ; Neural Pathways - drug effects ; Neural Pathways - physiology ; Neurons - drug effects ; Neurons - physiology ; Neuropeptides ; Norepinephrine ; Nutritional status ; Obesity ; Osteoblasts ; Osteogenesis - drug effects ; Osteogenesis - physiology ; Osteoporosis ; Osteoporosis - drug therapy ; Outflow ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Physiology ; Propranolol - pharmacology ; Receptors ; Receptors (physiology) ; Rodents ; Sympathetic nervous system ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology</subject><ispartof>The Lancet (British edition), 2003-11, Vol.362 (9395), p.1572-1574</ispartof><rights>2003 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Nov 8, 2003</rights><rights>Copyright Elsevier Limited Nov 8, 2003</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-ef837d907012ad4494ff64f9db7e5f938b325a6539a6efc07b00d3c4d9cef7f43</citedby><cites>FETCH-LOGICAL-c480t-ef837d907012ad4494ff64f9db7e5f938b325a6539a6efc07b00d3c4d9cef7f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15268143$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14615115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04138592$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cock, Terrie-Anne</creatorcontrib><creatorcontrib>Auwerx, Johan</creatorcontrib><title>Leptin: cutting the fat off the bone</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action.
Recently, Florent Elefteriou and colleagues (Endocrinology 2003; 144: 3842-47) found that hypothalamic neurons control bone mass. These researchers used monosodium glutamate to obliterate neurons in the arcuate nucleus. Previously, this group (Cell 2002; 101: 305-17) had shown that leptin inhibits bone formation by modulating the sympathetic nervous system. Although leptin influences both energy balance and bone mass by acting on the hypothalamus, the two processes involve different proteins and neurons. WHERE NEXT? Leptin has antiosteogenic activity in mice, mediated by hypothalamic nervous pathways and the sympathetic nervous system. Yet some human studies dispute leptin's antiosteogenic role. Large clinical studies are necessary to consolidate leptin's role in the physiology of human bone. In mice the beta blocker propranolol, a widely used drug with no major deleterious effects, significantly increases bone formation and bone mass without affecting bodyweight, a finding that may provide novel opportunities to design efficient bone-forming drugs for human beings.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Anorexia</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Blood pressure</subject><subject>Bone Density - drug effects</subject><subject>Bone Density - physiology</subject><subject>Bones</subject><subject>Brain stem</subject><subject>Cardiovascular diseases</subject><subject>Cocaine</subject><subject>Congenital diseases</subject><subject>Deletion</subject><subject>Density</subject><subject>Disease control</subject><subject>Energy</subject><subject>Energy balance</subject><subject>Energy Metabolism - drug effects</subject><subject>Energy Metabolism - physiology</subject><subject>Food</subject><subject>Genetics</subject><subject>Gold</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - physiology</subject><subject>In vivo methods and tests</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leptin</subject><subject>Leptin - pharmacology</subject><subject>Leptin - physiology</subject><subject>Life Sciences</subject><subject>Maintenance</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Mice</subject><subject>Mice, Obese</subject><subject>Nervous system</subject><subject>Neural Pathways - drug effects</subject><subject>Neural Pathways - physiology</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Neuropeptides</subject><subject>Norepinephrine</subject><subject>Nutritional status</subject><subject>Obesity</subject><subject>Osteoblasts</subject><subject>Osteogenesis - drug effects</subject><subject>Osteogenesis - physiology</subject><subject>Osteoporosis</subject><subject>Osteoporosis - drug therapy</subject><subject>Outflow</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cock, Terrie-Anne</au><au>Auwerx, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin: cutting the fat off the bone</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2003-11-08</date><risdate>2003</risdate><volume>362</volume><issue>9395</issue><spage>1572</spage><epage>1574</epage><pages>1572-1574</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action.
Recently, Florent Elefteriou and colleagues (Endocrinology 2003; 144: 3842-47) found that hypothalamic neurons control bone mass. These researchers used monosodium glutamate to obliterate neurons in the arcuate nucleus. Previously, this group (Cell 2002; 101: 305-17) had shown that leptin inhibits bone formation by modulating the sympathetic nervous system. Although leptin influences both energy balance and bone mass by acting on the hypothalamus, the two processes involve different proteins and neurons. WHERE NEXT? Leptin has antiosteogenic activity in mice, mediated by hypothalamic nervous pathways and the sympathetic nervous system. Yet some human studies dispute leptin's antiosteogenic role. Large clinical studies are necessary to consolidate leptin's role in the physiology of human bone. In mice the beta blocker propranolol, a widely used drug with no major deleterious effects, significantly increases bone formation and bone mass without affecting bodyweight, a finding that may provide novel opportunities to design efficient bone-forming drugs for human beings.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>14615115</pmid><doi>10.1016/S0140-6736(03)14747-2</doi><tpages>3</tpages></addata></record> |
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| subjects | Adrenergic beta-Antagonists - pharmacology Animals Anorexia Biochemistry, Molecular Biology Biological and medical sciences Biomedical materials Blood pressure Bone Density - drug effects Bone Density - physiology Bones Brain stem Cardiovascular diseases Cocaine Congenital diseases Deletion Density Disease control Energy Energy balance Energy Metabolism - drug effects Energy Metabolism - physiology Food Genetics Gold Hormones Humans Hypothalamus - drug effects Hypothalamus - physiology In vivo methods and tests Investigative techniques, diagnostic techniques (general aspects) Leptin Leptin - pharmacology Leptin - physiology Life Sciences Maintenance Medical sciences Metabolic diseases Mice Mice, Obese Nervous system Neural Pathways - drug effects Neural Pathways - physiology Neurons - drug effects Neurons - physiology Neuropeptides Norepinephrine Nutritional status Obesity Osteoblasts Osteogenesis - drug effects Osteogenesis - physiology Osteoporosis Osteoporosis - drug therapy Outflow Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Physiology Propranolol - pharmacology Receptors Receptors (physiology) Rodents Sympathetic nervous system Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology |
| title | Leptin: cutting the fat off the bone |
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