A Web of Circadian Pacemakers

The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationshi...

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Bibliographic Details
Published in:Cell 2002-12, Vol.111 (7), p.919-922
Main Authors: Schibler, Ueli, Sassone-Corsi, Paolo
Format: Article
Language:English
Subjects:
Animals
Biological Clocks - physiology
Cellular Biology
Circadian Rhythm - physiology
Cues
Eukaryotic Cells - physiology
Gene Expression Regulation - physiology
Humans
Life Sciences
Models, Animal
Suprachiasmatic Nucleus - physiology
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Summary:The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication mechanisms between central and peripheral clocks.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)01225-4