Emerging Anticancer Therapeutic Modalities Brought by Gold Complexes: Overview and Perspectives

The medicinal chemistry of gold has experienced an exponential development since the 2000s. For long, the mechanisms of action of gold complexes have been limited to direct coordination of the gold ion or supramolecular interactions of the whole gold complex with biomolecules. In the recent years, o...

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Bibliographic Details
Published in:European journal of inorganic chemistry 2023-09, Vol.26 (26)
Main Authors: Salmain, Michèle, Bertrand, Benoît
Format: Article
Language:English
Subjects:
Biomolecules
Cancer
Chemical Sciences
Coordination chemistry
Gold
Inorganic chemistry
Life Sciences
Medicinal Chemistry
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Summary:The medicinal chemistry of gold has experienced an exponential development since the 2000s. For long, the mechanisms of action of gold complexes have been limited to direct coordination of the gold ion or supramolecular interactions of the whole gold complex with biomolecules. In the recent years, other modes of action of gold‐based drug candidates have emerged. Herein, we review these new modalities, including photo‐induced cytotoxicity, selective protein modification and in cellulo catalysis.
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.202300340