Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy

The search for new metal-based photosensitizers (PSs) for anticancer photodynamic therapy (PDT) is a fast-developing field of research. Knowing that polymetallic complexes bear a high potential as PDT PSs, in this study, we aimed at combining the known photophysical properties of a rhenium(I) tricar...

Full description

Saved in:
Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2023-10, Vol.24 (19), p.e202300467-e202300467
Main Authors: Wang, Youchao, Felder, Patrick S, Mesdom, Pierre, Blacque, Olivier, Mindt, Thomas L, Cariou, Kevin, Gasser, Gilles
Format: Article
Language:English
Subjects:
Adenocarcinoma
Aqueous solutions
Chemical Sciences
Coordination chemistry
Coordination Complexes - pharmacology
Epithelium
Humans
Lung carcinoma
Medicinal Chemistry
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - pharmacology
Retinal pigment epithelium
Rhenium
Ruthenium
Ruthenium - pharmacology
Ruthenium compounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The search for new metal-based photosensitizers (PSs) for anticancer photodynamic therapy (PDT) is a fast-developing field of research. Knowing that polymetallic complexes bear a high potential as PDT PSs, in this study, we aimed at combining the known photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex to prepare a ruthenium-rhenium binuclear complex that could act as a PS for anticancer PDT. Herein, we present the synthesis and characterization of such a system and discuss its stability in aqueous solution. In addition, one of our complexes prepared, which localized in mitochondria, was found to have some degree of selectivity towards two types of cancerous cells: human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202300467