Nanocatalysis meets microfluidics: A powerful platform for sensitive bioanalysis

Accurate, sensitive, and highly selective detection of biological targets is of great significance in a wide range of domains, including clinical diagnosis, disease therapy, drug development, environmental monitoring, and food safety control. Recently, with advances in microfabrication and nanotechn...

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Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2023-01, Vol.158, p.116887, Article 116887
Main Authors: Gao, Yanfeng, Wang, Yanping, Wang, Yuzhen, Magaud, Pascale, Liu, Yuta, Zeng, Fei, Yang, Jingjing, Baldas, Lucien, Song, Yujun
Format: Article
Language:English
Subjects:
Bacteria analysis
Biomarker
Biosensor
Cell analysis
Chemical Sciences
Enzyme immobilization
Lab on a chip
Nanomaterial
Nanozyme
Point-of-care testing
Signal amplification
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Summary:Accurate, sensitive, and highly selective detection of biological targets is of great significance in a wide range of domains, including clinical diagnosis, disease therapy, drug development, environmental monitoring, and food safety control. Recently, with advances in microfabrication and nanotechnology, the combination of nanocatalysis and microfluidics has achieved great success in efficient bioanalysis benefiting from both components. This review aims to summarize the recent developments in nanocatalysis-assisted bioanalytical microfluidic devices involving extensively studied catalytically active nanomaterials, widely used microfluidic approaches, commonly adopted detection techniques, and their analytical applications for various biological targets, including small molecules, proteins, nucleic acids, cells, and bacteria. In addition, the benefits from integrated nanocatalysts, including signal conversion and signal amplification toward the improvement of detection sensitivity, are also highlighted. Ultimately, we discuss the key challenges and future development trends of nanocatalysis-assisted microfluidics, expecting to provide guidance for point-of-care testing devices suitable for practical use. •Recent advances and classification of catalytically active nanomaterials are introduced.•Advantages of nanocatalysts and microfluidics are separately highlighted.•Applications of nanocatalysis-assisted microfluidics in bioanalysis are summarized.•Prospects of commercialized nanocatalysis-assisted microfluidic devices are discussed.
ISSN:0165-9936
1879-3142
0165-9936
DOI:10.1016/j.trac.2022.116887