Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex

The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages. Results from phyloge...

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Bibliographic Details
Published in:Research in microbiology 2023-09, Vol.174 (7), p.104113-104113, Article 104113
Main Authors: Crestani, Chiara, Arcari, Gabriele, Landier, Annie, Passet, Virginie, Garnier, Dorian, Brémont, Sylvie, Armatys, Nathalie, Carmi-Leroy, Annick, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain
Format: Article
Language:English
Subjects:
Corynebacterium diphtheriae species complex
Corynebacterium ramonii
Corynebacterium ulcerans
Genome sequencing
Human health and pathology
Infectious diseases
Life Sciences
Taxonomy
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Summary:The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages. Results from phylogenetic analyses, in silico DNA–DNA hybridization (DDH) and MALDI-TOF spectra differentiate lineage 2 from C. ulcerans lineage 1, which, together with their distinct transmission dynamics (probable human-to-human vs animal-to-human), indicates that lineage 2 is a separate Corynebacterium species, which we propose to name Corynebacterium ramonii. This species is of particular medical interest considering that its human-to-human transmission is likely, and that some C. ramonii isolates carry the diphtheria toxin gene.
ISSN:0923-2508
1769-7123
0923-2508
DOI:10.1016/j.resmic.2023.104113