Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome?

The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model...

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Bibliographic Details
Published in:Multiple Sclerosis Journal 2023-02, Vol.29 (2), p.160-168
Main Authors: Degraeve, Béatrice, Sequeira, Henrique, Mecheri, Halima, Lenne, Bruno
Format: Article
Language:English
Subjects:
Cerebrum
Cognition
Cognitive ability
Cognitive Dysfunction
Cognitive science
Corpus callosum
Corpus Callosum - pathology
Humans
Information processing
Leukoencephalopathies - pathology
Multiple Sclerosis
Nervous system diseases
Neuroscience
Psychology
Structure-function relationships
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Summary:The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model of callosal disconnection syndrome is a valid model for MS. For this purpose, we will first review structural and functional evidence of callosal pathology in MS. Second, we will account for the potential role of CC abnormalities in MS-related dysfunctions. Finally, we will report data concurring with a “multiple disconnection hypothesis” that has been proposed to explain those dysfunctions, and we will examine evidence pointing toward MS as a “callosal disconnection syndrome.” We will end by discussing the contribution of this interpretation to the understanding of MS and MS-related deficits.
ISSN:1352-4585
1477-0970
DOI:10.1177/13524585221091067