Comparison of screening strategies with two new tests to score and diagnose varices needing treatment

We aimed to improve non-invasive screening of varices needing treatment (VNT) and compare different screening strategies. 2,290 patients with chronic liver disease were included in a retrospective study. Etiologies were: virus: 50.0%, NAFLD: 29.5%, alcohol: 20.5%, VNT: 14.9%. Test descriptors were p...

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Published in:Clinics and research in hepatology and gastroenterology 2022-08, Vol.46 (7), p.101925-101925, Article 101925
Main Authors: Calès, Paul, Ravaioli, Federico, Berger, Arthur, Farcau, Oana, Festi, Davide, Stefanescu, Horia, Vitellius, Carole, Nahon, Pierre, Bureau, Christophe, Ganne-Carriè, Nathalie, Berzigotti, Annalisa, de Ledinghen, Victor, Petta, Salvatore
Format: Article
Language:English
Subjects:
Elasticity Imaging Techniques - methods
Elastometry
Esophageal and Gastric Varices - diagnosis
Esophageal and Gastric Varices - etiology
Humans
Life Sciences
Liver Cirrhosis - diagnosis
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnosis
Non-invasive test
Oesophageal varices
Platelet Count
Portal hypertension
Retrospective Studies
Screening
Varicose Veins
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Summary:We aimed to improve non-invasive screening of varices needing treatment (VNT) and compare different screening strategies. 2,290 patients with chronic liver disease were included in a retrospective study. Etiologies were: virus: 50.0%, NAFLD: 29.5%, alcohol: 20.5%, VNT: 14.9%. Test descriptors were performance (spared endoscopy) and safety (missed VNT). VNT tests were evaluated according to their safety levels either for individual screening (95% negative predictive value (NPV)), population screening (95% sensitivity) or undifferentiated screening (100% sensitivity/NPV) without missed VNT. The tests provided three categories: missed VNT
ISSN:2210-7401
2210-741X
DOI:10.1016/j.clinre.2022.101925