Breast cancer and organ transplantation: Systematic review and meta-analysis

• Published in: Gynécologie, obstétrique, fertilité & sénologie obstétrique, fertilité & sénologie, 2023-01, Vol.51 (1), p.60-72
• Main Authors: Lapointe, M, Kerbaul, F, Meckert, F, Cognard, N, Mathelin, C, Lodi, M
• Format: Article
• Language: eng ; fre
• Subjects: Breast Neoplasms - epidemiology; Cancer; Female; Humans; Life Sciences; Organ Transplantation; Tissue and Organ Procurement; Tissue Donors
• ISSN: 2468-7189; 2468-7189
• DOI: 10.1016/j.gofs.2022.11.002

Our main objective was to investigate donor-transmitted epithelial cancers of all origins in comparison with breast cancers, with analysis of the carcinological outcome of recipients. Our secondary objective was to define medical check-up to be performed before any organ procurement from a donor with a history of breast cancer. We performed a systematic review of the literature up to June 1st 2022 by including all original articles (including clinical cases) reporting cases of epithelial cancer transmitted from donor to recipient, followed by a meta-analysis of epidemiological and survival data. In total, we included 52 articles (31 clinical cases and 21 cohort studies), representing 91,388 donors, 236,142 recipients, and 2591 cases of transmitted cancer. The risk of transmitted cancer was significantly higher with a history of breast cancer compared with a history of other cancer (RR=9.48 P=0.0025). In clinical cases, the pre-donation check-up was specified in only 33.3% of publications. The time between transplantation and cancer occurrence was longer in cases of breast cancer transmission compared to other epithelial cancers: 1435.8 days versus 297.6 (P