Full factorial optimization of α-aminophosphonates synthesis using diphenylphosphinic acid as efficient organocatalyst

Diphenylphosphinic acid was used as an efficient and simple catalyst for the synthesis of the α- aminophosphonates by multicomponent Kabachnik-Fields reaction in one pot of aromatic aldehyde, aniline and diethylphosphite . Three physicochemical factors including catalyst amount, reaction time and me...

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Published in:Reaction kinetics, mechanisms and catalysis mechanisms and catalysis, 2023-02, Vol.136 (1), p.165-182
Main Authors: Ferrah, Meriem, Guezane-Lakoud, Samia, Bendjeffal, Hacene, Aissa, Rym, Merabet-Khelassi, Mounia, Toffano, Martial, Aribi-Zouioueche, Louisa
Format: Article
Language:English
Subjects:
Catalysis
Chemical Sciences
Chemistry
Chemistry and Materials Science
Industrial Chemistry/Chemical Engineering
Organic chemistry
Physical Chemistry
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Summary:Diphenylphosphinic acid was used as an efficient and simple catalyst for the synthesis of the α- aminophosphonates by multicomponent Kabachnik-Fields reaction in one pot of aromatic aldehyde, aniline and diethylphosphite . Three physicochemical factors including catalyst amount, reaction time and medium temperature were optimized using a full factorial experiment design (FFD). Additionally, a quadratic polynomial regression model was applied for the analysis of the experimental data at a confidence level of 95% with p- values 
ISSN:1878-5190
1878-5204
DOI:10.1007/s11144-022-02329-0