Aptamer-guided nanomedicines for anticancer drug delivery

Aptamers are versatile nucleic acid-based macromolecules characterized by their high affinity and specificity to a specific target. Taking advantage of such binding properties, several aptamers have been selected to bind tumor biomarkers and have been used as targeting ligands for the functionalizat...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2018-09, Vol.134, p.122-137
Main Authors: Alshaer, Walhan, Hillaireau, Hervé, Fattal, Elias
Format: Article
Language:English
Subjects:
Aptamers
Cancer
Galenic pharmacology
Life Sciences
Liposomes
Micelles
Nanocarriers
Nanoparticles
Pharmaceutical sciences
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Summary:Aptamers are versatile nucleic acid-based macromolecules characterized by their high affinity and specificity to a specific target. Taking advantage of such binding properties, several aptamers have been selected to bind tumor biomarkers and have been used as targeting ligands for the functionalization of nanomedicines. Different functionalization methods have been used to link aptamers to the surface drug nanocarriers. The pre-clinical data of such nanomedicines overall show an enhanced and selective delivery of therapeutic payloads to cancer cells, thereby accelerating steps towards more effective therapeutic systems. This review describes the current advances in the use of aptamers as targeting moieties for the delivery of therapeutic and imaging agents to tumors by conjugation to organic and inorganic nanocarriers. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2018.09.011