Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues

We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-10, Vol.59 (86), p.12883-12886
Main Authors: Malikidogo, Kyangwi P, Isaac, Manon, Uguen, Adrien, Même, Sandra, Pallier, Agnès, Clémençon, Rudy, Morfin, Jean-François, Lacerda, Sara, Tóth, Éva, Bonnet, Célia S
Format: Article
Language:English
Subjects:
Bioaccumulation
Bioengineering
Chemical Sciences
Contrast agents
Coordination chemistry
Gadolinium
Imaging
Life Sciences
Serum albumin
Zinc
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Summary:We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents. We present the contradictory in vitro and in vivo behaviour of a Gd 3+ -based contrast agent that respond to Zn 2+ upon interaction with Human Serum Albumin.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc03137c