Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues

We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-10, Vol.59 (86), p.12883-12886
Main Authors: Malikidogo, Kyangwi P, Isaac, Manon, Uguen, Adrien, Même, Sandra, Pallier, Agnès, Clémençon, Rudy, Morfin, Jean-François, Lacerda, Sara, Tóth, Éva, Bonnet, Célia S
Format: Article
Language:English
Subjects:
Bioaccumulation
Bioengineering
Chemical Sciences
Contrast agents
Coordination chemistry
Gadolinium
Imaging
Life Sciences
Serum albumin
Zinc
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c343t-9aff3a60480bf53b9fab87b35380944ea9c5e202845d1b606a89686ffe37fcaf3
container_end_page 12886
container_issue 86
container_start_page 12883
container_title Chemical communications (Cambridge, England)
container_volume 59
creator Malikidogo, Kyangwi P
Isaac, Manon
Uguen, Adrien
Même, Sandra
Pallier, Agnès
Clémençon, Rudy
Morfin, Jean-François
Lacerda, Sara
Tóth, Éva
Bonnet, Célia S
description We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents. We present the contradictory in vitro and in vivo behaviour of a Gd 3+ -based contrast agent that respond to Zn 2+ upon interaction with Human Serum Albumin.
doi_str_mv 10.1039/d3cc03137c
format article
fullrecord <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04254714v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2881718198</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-9aff3a60480bf53b9fab87b35380944ea9c5e202845d1b606a89686ffe37fcaf3</originalsourceid><addsrcrecordid>eNpd0c9rHCEUB3AJKWSz7SX3gJBLEphWR51xclum-QVbAqWF0ou8cTUxzOpGnUD718fNhhTqRXl8eL7HF6EjSj5TwrovK6Y1YZS1eg_NKGt4Jbj8tb99i65qGRcH6DClR1IOFXKG1G_ndZWMTy67Z4O_fb_FOvgcIWUM98bndIHdehNiBq8NDhaPQcOINzEMBoPW03oaIbvgsfP477ZbdPoBZ5fSZNJH9MHCmMynt3uOfl5d_uhvquXd9W2_WFaacZarDqxl0BAuyWAFGzoLg2wHJpgkHecGOi1MTWrJxYoODWlAdo1srDWstRosm6OzXd8HGNUmujXEPyqAUzeLpdrWCK8Fbyl_psWe7mzZ4anMmNXaJW3GEbwJU1K1bIUUtC6_z9HJf_QxTNGXTYqStKWSdrKo853SMaQUjX2fgBK1zUV9ZX3_mktf8PEOx6Tf3b_c2AsDHoke</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2881718198</pqid></control><display><type>article</type><title>Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues</title><source>Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)</source><creator>Malikidogo, Kyangwi P ; Isaac, Manon ; Uguen, Adrien ; Même, Sandra ; Pallier, Agnès ; Clémençon, Rudy ; Morfin, Jean-François ; Lacerda, Sara ; Tóth, Éva ; Bonnet, Célia S</creator><creatorcontrib>Malikidogo, Kyangwi P ; Isaac, Manon ; Uguen, Adrien ; Même, Sandra ; Pallier, Agnès ; Clémençon, Rudy ; Morfin, Jean-François ; Lacerda, Sara ; Tóth, Éva ; Bonnet, Célia S</creatorcontrib><description>We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents. We present the contradictory in vitro and in vivo behaviour of a Gd 3+ -based contrast agent that respond to Zn 2+ upon interaction with Human Serum Albumin.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d3cc03137c</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Bioaccumulation ; Bioengineering ; Chemical Sciences ; Contrast agents ; Coordination chemistry ; Gadolinium ; Imaging ; Life Sciences ; Serum albumin ; Zinc</subject><ispartof>Chemical communications (Cambridge, England), 2023-10, Vol.59 (86), p.12883-12886</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-9aff3a60480bf53b9fab87b35380944ea9c5e202845d1b606a89686ffe37fcaf3</cites><orcidid>0000-0003-0228-8098 ; 0000-0003-3865-4379 ; 0000-0002-3200-6752 ; 0000-0002-3556-8283 ; 0000-0002-3765-0889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04254714$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Malikidogo, Kyangwi P</creatorcontrib><creatorcontrib>Isaac, Manon</creatorcontrib><creatorcontrib>Uguen, Adrien</creatorcontrib><creatorcontrib>Même, Sandra</creatorcontrib><creatorcontrib>Pallier, Agnès</creatorcontrib><creatorcontrib>Clémençon, Rudy</creatorcontrib><creatorcontrib>Morfin, Jean-François</creatorcontrib><creatorcontrib>Lacerda, Sara</creatorcontrib><creatorcontrib>Tóth, Éva</creatorcontrib><creatorcontrib>Bonnet, Célia S</creatorcontrib><title>Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues</title><title>Chemical communications (Cambridge, England)</title><description>We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents. We present the contradictory in vitro and in vivo behaviour of a Gd 3+ -based contrast agent that respond to Zn 2+ upon interaction with Human Serum Albumin.</description><subject>Bioaccumulation</subject><subject>Bioengineering</subject><subject>Chemical Sciences</subject><subject>Contrast agents</subject><subject>Coordination chemistry</subject><subject>Gadolinium</subject><subject>Imaging</subject><subject>Life Sciences</subject><subject>Serum albumin</subject><subject>Zinc</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0c9rHCEUB3AJKWSz7SX3gJBLEphWR51xclum-QVbAqWF0ou8cTUxzOpGnUD718fNhhTqRXl8eL7HF6EjSj5TwrovK6Y1YZS1eg_NKGt4Jbj8tb99i65qGRcH6DClR1IOFXKG1G_ndZWMTy67Z4O_fb_FOvgcIWUM98bndIHdehNiBq8NDhaPQcOINzEMBoPW03oaIbvgsfP477ZbdPoBZ5fSZNJH9MHCmMynt3uOfl5d_uhvquXd9W2_WFaacZarDqxl0BAuyWAFGzoLg2wHJpgkHecGOi1MTWrJxYoODWlAdo1srDWstRosm6OzXd8HGNUmujXEPyqAUzeLpdrWCK8Fbyl_psWe7mzZ4anMmNXaJW3GEbwJU1K1bIUUtC6_z9HJf_QxTNGXTYqStKWSdrKo853SMaQUjX2fgBK1zUV9ZX3_mktf8PEOx6Tf3b_c2AsDHoke</recordid><startdate>20231026</startdate><enddate>20231026</enddate><creator>Malikidogo, Kyangwi P</creator><creator>Isaac, Manon</creator><creator>Uguen, Adrien</creator><creator>Même, Sandra</creator><creator>Pallier, Agnès</creator><creator>Clémençon, Rudy</creator><creator>Morfin, Jean-François</creator><creator>Lacerda, Sara</creator><creator>Tóth, Éva</creator><creator>Bonnet, Célia S</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-0228-8098</orcidid><orcidid>https://orcid.org/0000-0003-3865-4379</orcidid><orcidid>https://orcid.org/0000-0002-3200-6752</orcidid><orcidid>https://orcid.org/0000-0002-3556-8283</orcidid><orcidid>https://orcid.org/0000-0002-3765-0889</orcidid></search><sort><creationdate>20231026</creationdate><title>Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues</title><author>Malikidogo, Kyangwi P ; Isaac, Manon ; Uguen, Adrien ; Même, Sandra ; Pallier, Agnès ; Clémençon, Rudy ; Morfin, Jean-François ; Lacerda, Sara ; Tóth, Éva ; Bonnet, Célia S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-9aff3a60480bf53b9fab87b35380944ea9c5e202845d1b606a89686ffe37fcaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bioaccumulation</topic><topic>Bioengineering</topic><topic>Chemical Sciences</topic><topic>Contrast agents</topic><topic>Coordination chemistry</topic><topic>Gadolinium</topic><topic>Imaging</topic><topic>Life Sciences</topic><topic>Serum albumin</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malikidogo, Kyangwi P</creatorcontrib><creatorcontrib>Isaac, Manon</creatorcontrib><creatorcontrib>Uguen, Adrien</creatorcontrib><creatorcontrib>Même, Sandra</creatorcontrib><creatorcontrib>Pallier, Agnès</creatorcontrib><creatorcontrib>Clémençon, Rudy</creatorcontrib><creatorcontrib>Morfin, Jean-François</creatorcontrib><creatorcontrib>Lacerda, Sara</creatorcontrib><creatorcontrib>Tóth, Éva</creatorcontrib><creatorcontrib>Bonnet, Célia S</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malikidogo, Kyangwi P</au><au>Isaac, Manon</au><au>Uguen, Adrien</au><au>Même, Sandra</au><au>Pallier, Agnès</au><au>Clémençon, Rudy</au><au>Morfin, Jean-François</au><au>Lacerda, Sara</au><au>Tóth, Éva</au><au>Bonnet, Célia S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2023-10-26</date><risdate>2023</risdate><volume>59</volume><issue>86</issue><spage>12883</spage><epage>12886</epage><pages>12883-12886</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>We present the in vitro characterisation of a Gd 3+ -based contrast agent that responds to Zn 2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd 3+ -accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents. We present the contradictory in vitro and in vivo behaviour of a Gd 3+ -based contrast agent that respond to Zn 2+ upon interaction with Human Serum Albumin.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d3cc03137c</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-0228-8098</orcidid><orcidid>https://orcid.org/0000-0003-3865-4379</orcidid><orcidid>https://orcid.org/0000-0002-3200-6752</orcidid><orcidid>https://orcid.org/0000-0002-3556-8283</orcidid><orcidid>https://orcid.org/0000-0002-3765-0889</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1359-7345
ispartof Chemical communications (Cambridge, England), 2023-10, Vol.59 (86), p.12883-12886
issn 1359-7345
1364-548X
language eng
recordid cdi_hal_primary_oai_HAL_hal_04254714v1
source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Bioaccumulation
Bioengineering
Chemical Sciences
Contrast agents
Coordination chemistry
Gadolinium
Imaging
Life Sciences
Serum albumin
Zinc
title Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T15%3A15%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zinc-sensitive%20MRI%20contrast%20agents:%20importance%20of%20local%20probe%20accumulation%20in%20zinc-rich%20tissues&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Malikidogo,%20Kyangwi%20P&rft.date=2023-10-26&rft.volume=59&rft.issue=86&rft.spage=12883&rft.epage=12886&rft.pages=12883-12886&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/d3cc03137c&rft_dat=%3Cproquest_hal_p%3E2881718198%3C/proquest_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c343t-9aff3a60480bf53b9fab87b35380944ea9c5e202845d1b606a89686ffe37fcaf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2881718198&rft_id=info:pmid/&rfr_iscdi=true