TRPs and Ca2+ in cell death and survival

[Display omitted] •TRP channels generate distinct intracellular calcium signals that regulate downstream pathways converging to cell death or survival.•Despite sharing homologies, TRP channels from a same family can be associated either to cell death or cell survival.•A single TRP channel can be ass...

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2018-01, Vol.69, p.4-18
Main Authors: Fliniaux, Ingrid, Germain, Emmanuelle, Farfariello, Valerio, Prevarskaya, Natalia
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Autophagy
Calcium
Cell Death
Cell Survival
Cellular Biology
Humans
Life Sciences
Survival
Transient Receptor Potential Channels
TRP channels
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Summary:[Display omitted] •TRP channels generate distinct intracellular calcium signals that regulate downstream pathways converging to cell death or survival.•Despite sharing homologies, TRP channels from a same family can be associated either to cell death or cell survival.•A single TRP channel can be associated either to cell death or survival depending on the cellular or environmental context. Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to environmental stimuli. Pharmacological or genetic manipulations of TRP channels demonstrate that TRP channels influence cell death rates, prolonging or shortening of cell survival. Due to their diverse cellular localization, TRP channels mediated Ca2+ influx generates distinct intracellular Ca2+ signals that regulate downstream pathways converging to apoptosis or survival. In this review, we summarize the accumulated knowledge focused on how TRP channel regulate cell fate and may affect different pathologies including cardiovascular, neurological, metabolic or neoplastic disorders.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2017.07.002