On the physicochemical properties, setting chemical reaction, and in vitro bioactivity of aragonite–chitosan composite cement as a bone substitute

In the field of bone substitution, calcium carbonate cements have been proposed as bioactive mineral cements complementary to calcium phosphate cements for applications requiring a faster resorption rate. We investigated for the first time the setting chemical reaction, physicochemical properties an...

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Bibliographic Details
Published in:New journal of chemistry 2023-02, Vol.47 (6), p.2771-2786
Main Authors: Toufik, E., Noukrati, H., Rey, C., Marsan, O., Charvillat, C., Cazalbou, S., Ben Youcef, H., Barroug, A., Combes, C.
Format: Article
Language:English
Subjects:
Apatite
Aragonite
Biological activity
Biomedical materials
Biomimetics
Body fluids
Calcite
Calcium carbonate
Calcium phosphates
Cement
Cements
Chemical reactions
Chitosan
Compressive strength
Crystallization
Engineering Sciences
Evolution
In vitro methods and tests
Injectability
Magnesium
Materials
Materials substitution
Recrystallization
Substitute bone
Substitution reactions
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Summary:In the field of bone substitution, calcium carbonate cements have been proposed as bioactive mineral cements complementary to calcium phosphate cements for applications requiring a faster resorption rate. We investigated for the first time the setting chemical reaction, physicochemical properties and the in vitro evolution in a simulated body fluid (SBF) of calcium carbonate composite cements including chitosan (1.5 wt%, 2.5 wt%, 3.5 wt%, and 4 wt%) in view of bone applications. We implemented a methodology based on the X-ray diffraction data for the quantitative analysis of the four calcium carbonate phases (aragonite, vaterite, calcite and amorphous calcium carbonate) involved in the composite cement setting which allowed determining the setting chemical mechanism and the underlying effect of chitosan. Interestingly, aragonite was the main phase in all the set composite cements. Whatever the chitosan amount, we showed that the initial Mg-stabilised amorphous calcium carbonate crystallised rapidly into a small amount of magnesium-doped calcite (
ISSN:1144-0546
1369-9261
DOI:10.1039/D2NJ05515E