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Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases

In the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels...

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Bibliographic Details
Published in:International journal of hematology 2021-08, Vol.114 (2), p.222-227
Main Authors: Mahe, Kristell, Couturaud, Francis, Kerspern, Hélène, Chauveau, Aurélie, Ianotto, Jean-Christophe
Format: Article
Language:English
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Summary:In the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. A cohort of 257 patients (123 PV; 134 SP) was identified. The median B2m level was higher for PV patients (3.16 vs 1.98 mg/l, p  
ISSN:0925-5710
1865-3774
0925-5710
DOI:10.1007/s12185-021-03164-0