Gastrointestinal bleeding from angiodysplasia in von Willebrand disease: Improved diagnosis and outcome prediction using videocapsule on top of conventional endoscopy

• Published in: Journal of thrombosis and haemostasis 2021-02, Vol.19 (2), p.380-386
• Main Authors: Rauch, Antoine, Paris, Camille, Repesse, Yohann, Branche, Julien, D’Oiron, Roseline, Harroche, Annie, Ternisien, Catherine, Castet, Sabine‐Marie, Lebreton, Aurélien, Pan‐Petesch, Brigitte, Volot, Fabienne, Claeyssens, Segolene, Chamouni, Pierre, Gay, Valérie, Berger, Claire, Desprez, Dominique, Falaise, Céline, Biron Andreani, Christine, Marichez, Catherine, Pradines, Benedicte, Zawadzki, Christophe, Itzhar Baikian, Nathalie, Borel‐Derlon, Annie, Goudemand, Jenny, Gerard, Romain, Susen, Sophie
• Format: Article
• Language: English
• Subjects: angiodysplasia; Angiodysplasia - complications; Angiodysplasia - diagnosis; Antidepressants; argon plasma coagulation; Bleeding; Endoscopy; gastrointestinal bleeding; Gastrointestinal Hemorrhage - diagnosis; Genotypes; Humans; Life Sciences; Localization; Patients; Phenotypes; Prognosis; Small intestine; Survival; video capsule endoscopy; von Willebrand disease; von Willebrand Diseases - complications; von Willebrand Diseases - diagnosis
• ISSN: 1538-7933; 1538-7836; 1538-7836
• DOI: 10.1111/jth.15155

Background Despite a high prevalence of angiodysplasia, no specific guidelines are available for the modalities of endoscopic exploration of gastrointestinal (GI) bleeding in von Willebrand disease (VWD). Whether VWD patients could benefit from video capsule endoscopy (VCE) looking for angiodysplasia eligible to endoscopic treatment or at high risk of bleeding is unknown. Objectives To assess the diagnostic efficacy for angiodysplasia and the prognostic value of VCE on top of conventional endoscopy in VWD patients with GI bleeding. Patients/Methods A survey was sent to the 30 centers of the French‐network on inherited bleeding disorders to identify VWD patients referred for endoscopic exploration of GI bleeding from January 2015 to December 2017. Data obtained included patient characteristics, VWD phenotype/genotype, GI bleeding pattern, results of endoscopic investigations, and medical management applied including endoscopic therapy. We assessed by Kaplan‐Meier analysis the recurrence‐free survival after the first GI bleeding event according to endoscopic categorization and, in patients with angiodysplasia, to the presence of small‐bowel localizations on VCE exploration. Results GI bleeding source localization was significantly improved when including VCE exploration (P