Atypical inter‐hemispheric communication correlates with altered motor inhibition during learning of a new bimanual coordination pattern in developmental coordination disorder

• Published in: Developmental science 2018-05, Vol.21 (3), p.e12563-n/a
• Main Authors: Blais, Mélody, Amarantini, David, Albaret, Jean‐Michel, Chaix, Yves, Tallet, Jessica
• Format: Article
• Language: English
• Subjects: Accuracy; Adolescents; Brain Hemisphere Functions; Communication; Comparative Analysis; Control Groups; Coordination; Correlation; EEG; Learning Problems; Life Sciences; Motor Development; Motor skill; Motor skill learning; Neurodevelopmental disorders; Neuroimaging; Neurological Impairments; Physical Disabilities; Psychomotor Skills; Task Analysis
• ISSN: 1363-755X; 1467-7687; 1467-7687
• DOI: 10.1111/desc.12563

Impairment of motor learning skills in developmental coordination disorder (DCD) has been reported in several studies. Some hypotheses on neural mechanisms of motor learning deficits in DCD have emerged but, to date, brain‐imaging investigations are scarce. The aim of the present study is to assess possible changes in communication between brain areas during practice of a new bimanual coordination task in teenagers with DCD (n = 10) compared to matched controls (n = 10). Accuracy, stability and number of mirror movements were computed as behavioural variables. Neural variables were assessed by electroencephalographic coherence analyses of intra‐hemispheric and inter‐hemispheric fronto‐central electrodes. In both groups, accuracy of the new coordination increased concomitantly with right intra‐hemispheric fronto‐central coherence. Compared to typically developing teenagers, DCD teenagers presented learning difficulties expressed by less stability, no stabilization of the new coordination and a greater number of mirror movements despite practice. These measures correlated with reduced inter‐hemispheric communication, even after practice of the new coordination. For the first time, these findings provide neuro‐imaging evidence of a kind of inter‐hemispheric ‘disconnection’ related to altered inhibition of mirror movements during motor learning in DCD. Compared to typically developing teenagers, teenagers with Developmental Coordination Disorder (DCD) present learning difficulties of a new bimanual coordination as revealed by a greater number of mirror movements despite practice. This measure is correlated with a reduced inter‐hemispheric communication even after practice of the new coordination. For the first time, these findings provide neuro‐imaging evidence of a kind of inter‐hemispheric ‘disconnection’ related to altered inhibition of mirror movements during motor learning in DCD.