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Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues
Abstract Like all obligate intracellular pathogens, influenza A virus (IAV) reprograms host cell’s glucose and lipid metabolism to promote its own replication. However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy homeostasis, has no...
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Published in: | Communications biology 2020-05, Vol.3 (1) |
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creator | Ayari, Asma Rosa-Calatrava, Manuel Lancel, Steve Barthelemy, Johanna Pizzorno, Andrés Mayeuf-Louchart, Alicia Baron, Morgane Hot, David Deruyter, Lucie Soulard, Daphnée Julien, Thomas Faveeuw, Christelle Molendi-Coste, Olivier Dombrowicz, David Sedano, Laura Sencio, Valentin Le Goffic, Ronan Trottein, François Wolowczuk, Isabelle |
description | Abstract Like all obligate intracellular pathogens, influenza A virus (IAV) reprograms host cell’s glucose and lipid metabolism to promote its own replication. However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy homeostasis, has not been yet characterized. Here, we show that influenza infection induces alterations in whole-body glucose metabolism that persist long after the virus has been cleared. We report depot-specific changes in the WAT of IAV-infected mice, notably characterized by the appearance of thermogenic brown-like adipocytes within the subcutaneous fat depot. Importantly, viral RNA- and viral antigen-harboring cells are detected in the WAT of infected mice. Using in vitro approaches, we find that IAV infection enhances the expression of brown-adipogenesis-related genes in preadipocytes. Overall, our findings shed light on the role that the white adipose tissue, which lies at the crossroads of nutrition, metabolism and immunity, may play in influenza infection. |
doi_str_mv | 10.1038/s42003-020-0965-6 |
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subjects | Life Sciences |
title | Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues |
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