Tetrathiafulvalene End-Functionalized Poly(N-isopropylacrylamide): A New Class of Amphiphilic Polymer for the Creation of Multistimuli Responsive Micelles

In this article, we report the formation of micelles from a tetrathiafulvalene (TTF) end-functionalized poly(N-isopropylacrylamide) (poly(NIPAM)) derivative (1). We have determined the critical aggregation concentration (CAC) and average diameter of the micelles using fluorescence spectroscopy and d...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2010-08, Vol.132 (31), p.10796-10801
Main Authors: Bigot, Julien, Charleux, Bernadette, Cooke, Graeme, Delattre, François, Fournier, David, Lyskawa, Joël, Sambe, Léna, Stoffelbach, François, Woisel, Patrice
Format: Article
Language:English
Subjects:
Acrylamides - chemistry
Acrylic Resins
Chemical Sciences
Fluorescent Dyes - chemistry
Heterocyclic Compounds - chemistry
Micelles
Models, Molecular
Molecular Structure
Oxazines - chemistry
Oxidation-Reduction
Particle Size
Polymers - chemistry
Spectrometry, Fluorescence
Surface Properties
Temperature
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Summary:In this article, we report the formation of micelles from a tetrathiafulvalene (TTF) end-functionalized poly(N-isopropylacrylamide) (poly(NIPAM)) derivative (1). We have determined the critical aggregation concentration (CAC) and average diameter of the micelles using fluorescence spectroscopy and dynamic light scattering experiments, respectively. We have exploited the NIPAM backbone of the polymer to thermally transform the swollen hydrophilic poly(NIPAM) derivative to a more globular hydrophobic state at the lower critical solution temperature (LCST). Finally, we have shown that we can exploit the chemical oxidation and complexation properties of the TTF unit to disrupt the micelle architecture to release the hydrophobic dye Nile Red from the interior of the micelle.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja1027452