Structure and pharmacology of swelling‐sensitive chloride channels, I Cl,swell

Since several years, the interest for chloride channels and more particularly for the enigmatic swelling‐activated chloride channel (I Cl,swell ) is increasing. Despite its well‐characterized electrophysiological properties, the I Cl,swell structure and pharmacology are not totally elucidated. These...

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Published in:Fundamental & clinical pharmacology 2003-10, Vol.17 (5), p.539-553
Main Authors: D'Anglemont De Tassigny, Alexandra, Souktani, Rachid, Ghaleh, Bijan, Henry, Patrick, Berdeaux, Alain
Format: Article
Language:English
Subjects:
Life Sciences
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Summary:Since several years, the interest for chloride channels and more particularly for the enigmatic swelling‐activated chloride channel (I Cl,swell ) is increasing. Despite its well‐characterized electrophysiological properties, the I Cl,swell structure and pharmacology are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling‐activated chloride channels.
ISSN:0767-3981
1472-8206
DOI:10.1046/j.1472-8206.2003.00197.x