Selective serotonin reuptake inhibitors and fractures in older nursing home residents: Data from the INCUR study

•Depression and the use of selective serotonin reuptake inhibitors (SSRIs) are associated with osteoporosis.•SSRIs can increase fracture risk.•SSRIs are associated with fractures in nursing home residents.•A regular medication review should be performed to reduce inappropriate prescriptions and rela...

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Bibliographic Details
Published in:Maturitas 2022-04, Vol.158, p.37-39
Main Authors: Damanti, Sarah, Ramirez, Giuseppe Alvise, Da Prat, Valentina, Bertola, Ambra, Manzo, Emanuela, Vadruccio, Stefania, Tresoldi, Moreno, Barreto, Philipe de Souto, Rolland, Yves
Format: Article
Language:English
Subjects:
Aged
Bone Density
Fractures
Fractures, Bone - chemically induced
Fractures, Bone - epidemiology
Frailty
Humans
Life Sciences
Nursing Homes
Older people
Osteoporosis
Prospective Studies
Residents
Serotonin Uptake Inhibitors - adverse effects
SSRI
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Summary:•Depression and the use of selective serotonin reuptake inhibitors (SSRIs) are associated with osteoporosis.•SSRIs can increase fracture risk.•SSRIs are associated with fractures in nursing home residents.•A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences. Depression and selective serotonin reuptake inhibitors (SSRI) reduce bone mass and increase fracture risk. We analyzed the association between SSRI use and fractures development in nursing homes residents during a one-year prospective observational study. Sixty-four of the 800 participants developed a fracture during the one-year follow-up. Individuals who developed fractures used SSRIs more often than residents who did not (40.6% vs 28.7%, p =0.045). SSRIs were associated with fractures (adjusted OR 1.76, 95% CI 1.04 – 2.98, p = 0.036). A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2021.11.012