Pregnancy during TNFα antagonist therapy: Beware the rifampin-oral contraceptive interaction. Report of two cases

Abstract We report two cases of pregnancy in patients taking TNFα antagonists for chronic inflammatory joint disease. A factor in both pregnancies was the use of rifampin concomitantly with a combined oral contraceptive. Both patients were taking rifampin and isoniazid for tuberculosis prophylaxis i...

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Bibliographic Details
Published in:Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2010-05, Vol.77 (3), p.268-270
Main Authors: Wibaux, Cécile, Andrei, Irina, Paccou, Julien, Philippe, Peggy, Biver, Emmanuel, Duquesnoy, Bernard, Flipo, René Marc
Format: Article
Language:English
Subjects:
Contraception
Drug-drug interactions
Internal Medicine
Life Sciences
Pregnancy
Rheumatology
Rifampin
TNFα antagonists
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Summary:Abstract We report two cases of pregnancy in patients taking TNFα antagonists for chronic inflammatory joint disease. A factor in both pregnancies was the use of rifampin concomitantly with a combined oral contraceptive. Both patients were taking rifampin and isoniazid for tuberculosis prophylaxis in compliance with French recommendations for patients with positive intradermal tuberculin tests who are scheduled to receive biotherapeutic agents.
ISSN:1297-319X
DOI:10.1016/j.jbspin.2010.02.001