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A mild and selective method for N-Boc deprotection

A new mild method to remove N- tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid- and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2002-01, Vol.43 (4), p.589-591
Main Authors: Routier, Sylvain, Saugé, Laurence, Ayerbe, Nathalie, Coudert, Gérard, Mérour, Jean-Yves
Format: Article
Language:English
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Summary:A new mild method to remove N- tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid- and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)02225-0