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A mild and selective method for N-Boc deprotection
A new mild method to remove N- tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid- and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes. Graphic
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Published in: | Tetrahedron letters 2002-01, Vol.43 (4), p.589-591 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A new mild method to remove
N-
tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding
N-free products are obtained in good yields. The reactions are selective for acid- and base-sensitive groups, such as
tert-butyl and alkyl esters, aldehydes.
Graphic |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(01)02225-0 |