Non-toxigenic Corynebacterium diphtheriae in hallux ulceration

Introduction: Toxigenic Corynebacterium diphtheriae causes classical diphtheria. Skin infections by toxigenic or non-toxigenic Corynebacterium diphtheriae are prevalent in the tropics but are rarely reported. Case presentation: We report the identification of a non-toxigenic Corynebacterium diphther...

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Published in:Journal of infection in developing countries 2022-06, Vol.16 (6), p.1118-1121
Main Authors: Delvallez, Gauthier, Badell, Edgar, Cheng, Sokleaph, Meng, Soda, Tong, Vivandet, Norman, Judy, Toubiana, Julie, Vandelannoote, Koen, Bañuls, Anne-Laure, Hide, Mallorie, Brisse, Sylvain
Format: Article
Language:English
Subjects:
Antibiotics
Case reports
Diphtheria
Drug resistance
E coli
Immunization
Infections
Life Sciences
Pathogens
Penicillin
Vaccines
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Summary:Introduction: Toxigenic Corynebacterium diphtheriae causes classical diphtheria. Skin infections by toxigenic or non-toxigenic Corynebacterium diphtheriae are prevalent in the tropics but are rarely reported. Case presentation: We report the identification of a non-toxigenic Corynebacterium diphtheriae (biovar Gravis) isolate in a 52-year-old Cambodian male. The patient presented purulent and non-healing ulcerations on the right hallux. The wound has healed after 7 days of antibiotic therapy with a favourable outcome. Conclusions: This case represents, to our knowledge, the first report of Corynebacterium diphtheriae in Cambodia in the last 10 years, and highlights the lack of diagnosis and notifications of diphtheria. It is important to raise awareness among clinicians and to set up diphtheria surveillance in Cambodia.
ISSN:1972-2680
2036-6590
1972-2680
DOI:10.3855/jidc.16153