Low endocan levels are predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock

Endocan is a circulating proteoglycan measured at high blood levels during severe sepsis, with a likely lung anti-inflammatory function. The aim of this study was to assess whether paradoxically low endocan levels at Intensive Care Unit (ICU) admission could predict Acute Respiratory Distress Syndro...

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Bibliographic Details
Published in:Journal of critical care 2018-10, Vol.47, p.121-126
Main Authors: Gaudet, Alexandre, Parmentier, Erika, Dubucquoi, Sylvain, Poissy, Julien, Duburcq, Thibault, Lassalle, Philippe, De Freitas Caires, Nathalie, Mathieu, Daniel
Format: Article
Language:English
Subjects:
ARDS
Biomarker
Critical care
Endothelium
Failure
Inflammation
Life Sciences
Mortality
Multiple organ dysfunction syndrome
Renal replacement therapy
Respiratory distress syndrome
Sepsis
Ventilators
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Summary:Endocan is a circulating proteoglycan measured at high blood levels during severe sepsis, with a likely lung anti-inflammatory function. The aim of this study was to assess whether paradoxically low endocan levels at Intensive Care Unit (ICU) admission could predict Acute Respiratory Distress Syndrome (ARDS) within 72 h in severe septic patients. Patients admitted for severe sepsis in the ICU of a French University Hospital were included in a prospective single-center observational study between October 2014 and March 2016. 72 patients admitted in ICU for severe sepsis were included. Endocan blood values at inclusion were significantly lower in patients who developed an ARDS at 72 h (p  5.36 ng/mL, the adjusted OR for development of ARDS at 72 h was of 0.001 (95% CI 0–0.215; p = 0.011). In our cohort, an endocan value 
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2018.06.018