Parallel Screening with 14 C‐Labeled Carbon Dioxide: De‐risking the Staudinger‐Aza‐Wittig Reaction

Carbon isotope labeling is a useful technology for tracking the fate of organic compounds in the environment and in living organisms. In this context, the development of robust and general methodologies amenable to the direct functionalization of CO 2 remains a significant task. In this communicatio...

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Published in:European journal of organic chemistry 2022-08, Vol.2022 (30)
Main Authors: Babin, Victor, Sallustrau, Antoine, Molins, Maxime, Labiche, Alexandre, Goudet, Amélie, Taran, Frédéric, Audisio, Davide
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container_issue 30
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container_title European journal of organic chemistry
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creator Babin, Victor
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description Carbon isotope labeling is a useful technology for tracking the fate of organic compounds in the environment and in living organisms. In this context, the development of robust and general methodologies amenable to the direct functionalization of CO 2 remains a significant task. In this communication, a de‐risking approach was developed to evaluate the robustness of the Staudinger aza‐Wittig sequence for carbon isotope labeling. This technology is based on [ 14 C]CO 2 screening that allowed to investigate the tolerance of the procedure with most representative heterocycles and functional groups found in FDA approved drugs.
doi_str_mv 10.1002/ejoc.202200133
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title Parallel Screening with 14 C‐Labeled Carbon Dioxide: De‐risking the Staudinger‐Aza‐Wittig Reaction
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