CinNapht AIE(E)gens for selective imaging of lipid droplets

This article describes the synthesis and photophysical properties of Aggregation-Induced Emission (enhancement) luminogens derivated from CinNaphts dyes. These fluorophores can be obtained in good yields in a single SNAr step of a fluorinated CinNapht derivative by incorporating hindered aromatic am...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-04, Vol.22 (14), p.2739-2743
Main Authors: Tacke, Eléonore, Hoang, Minh-Duc, Estaque, Lilian, Durand, Philippe, Pieters, Grégory, Chevalier, Arnaud
Format: Article
Language:English
Subjects:
Aggregation
Amines
Aromatic compounds
Carbazole
Carbazoles
Chemical compounds
Chemical Sciences
Droplets
Dyes
Emission
Emissions
Fluorescence
Fluorophores
Imaging techniques
Lipids
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Summary:This article describes the synthesis and photophysical properties of Aggregation-Induced Emission (enhancement) luminogens derivated from CinNaphts dyes. These fluorophores can be obtained in good yields in a single SNAr step of a fluorinated CinNapht derivative by incorporating hindered aromatic amines. They exhibit AIE(E) behavior associated with solid-state fluorescence covering an emission range from 563 to 722 nm. One carbazole derivative demonstrates a remarkable efficiency in imaging lipid droplets in living cells through an original photophysical mechanism. The use of hindered aromatic amines in a SNAr reaction enabled the synthesis of novel AIE(E)gens derivatives of CinNaphts, suitable for fluorescence imaging of lipid droplets in living cells.
ISSN:1477-0520
1477-0539
DOI:10.1039/d4ob00247d