Mild untreated hypercholesterolaemia affects mechanical properties of the Achilles tendon but not gastrocnemius muscle

Tendon xanthoma and altered mechanical properties have been demonstrated in people with familial hypercholesterolaemia. However, it is unclear whether mild, untreated hypercholesterolaemia alters musculotendinous mechanical properties and muscle architecture. We conducted a case-control study of adu...

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Bibliographic Details
Published in:Journal of biomechanics 2024-03, Vol.166, p.112048-112048, Article 112048
Main Authors: Coombes, Brooke K, Hanna, Monica, Thompson, Kaelah A., Coppieters, Michel W., Dick, Taylor J.M., Andrade, Ricardo J, Barber, Lee
Format: Article
Language:English
Subjects:
Achilles tendon
Achilles Tendon - physiology
Adult
Adults
Aged
Ankle
Case-Control Studies
Cholesterol
Diabetes
Electromyography
Gastrocnemius muscle
Humans
Hypercholesterolemia
Life Sciences
Low density lipoprotein
Mechanical properties
Middle Aged
Muscle function
Muscle, Skeletal - physiology
Muscles
Musculoskeletal system
Stiffness
Tendon Injuries
Tendons
Tensile stress
Ultrasonography
Wave velocity
Xanthoma
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Summary:Tendon xanthoma and altered mechanical properties have been demonstrated in people with familial hypercholesterolaemia. However, it is unclear whether mild, untreated hypercholesterolaemia alters musculotendinous mechanical properties and muscle architecture. We conducted a case-control study of adults aged 50 years and over, without lower limb injury or history of statin medication. Based on fasting low-density lipoprotein (LDL) cholesterol levels, 6 participants had borderline high LDL (>3.33 mmol/L) and 6 had optimal LDL cholesterol (
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2024.112048