Outcome of children and adolescents with central nervous system tumors in phase I trials

Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the outcome of children and adolescents with CNS tumors participating in phase I trials within the Innovative Therapies for Children with Cancer...

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Bibliographic Details
Published in:Journal of neuro-oncology 2018-03, Vol.137 (1), p.83-92
Main Authors: Carceller, Fernando, Bautista, Francisco, Jiménez, Irene, Hladun-Álvaro, Raquel, Giraud, Cécile, Bergamaschi, Luca, Dandapani, Madhumita, Aerts, Isabelle, Doz, François, Frappaz, Didier, Casanova, Michela, Morland, Bruce, Hargrave, Darren R., Vassal, Gilles, Pearson, Andrew D. J., Geoerger, Birgit, Moreno, Lucas, Marshall, Lynley V.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Antitumor agents
Brain cancer
Cancer
Central nervous system
Central Nervous System Neoplasms - diagnosis
Central Nervous System Neoplasms - therapy
Child
Child, Preschool
Children
Clinical Study
Clinical trials
Clinical Trials, Phase I as Topic
Disease Progression
Female
Humans
Infant
Kaplan-Meier Estimate
Life Sciences
Male
Medical innovations
Medicine
Medicine & Public Health
Medulloblastoma
Multivariate analysis
Nervous system
Nervous system diseases
Neurology
Oncology
Outcome Assessment (Health Care)
Solid tumors
Survival
Teenagers
Toxicity
Treatment Outcome
Tumors
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Description
Summary:Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the outcome of children and adolescents with CNS tumors participating in phase I trials within the Innovative Therapies for Children with Cancer (ITCC) consortium. Patients with solid tumors aged 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-017-2698-z