Airway complications in lung transplant recipients with telomere‐related interstitial lung disease

Introduction Patients with short telomere‐related interstitial lung disease (ILD) have worse outcomes after lung transplantation. We hypothesized that post‐transplant airway complications, including dehiscence and bronchial stenosis, would be more common in the short telomere ILD lung transplant pop...

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Published in:Clinical transplantation 2022-03, Vol.36 (3), p.e14552-n/a
Main Authors: Choi, Bina, Messika, Jonathan, Courtwright, Andrew, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Le Pavec, Jérôme, Quêtant, Sébastien, Froidure, Antoine, Lazor, Romain, Reynaud‐Gaubert, Martine, Borgne, Aurélie Le, Houlbracq, Mathilde Phillips, Goldberg, Hilary, El‐Chemaly, Souheil, Borie, Raphael
Format: Article
Language:English
Subjects:
Constriction, Pathologic - complications
Female
Humans
Life Sciences
Lung
Lung Diseases, Interstitial - genetics
Lung Diseases, Interstitial - surgery
lung transplantation
Lung Transplantation - adverse effects
pulmonary fibrosis
Retrospective Studies
telomerase
telomere
Telomere - genetics
Transplant Recipients
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Summary:Introduction Patients with short telomere‐related interstitial lung disease (ILD) have worse outcomes after lung transplantation. We hypothesized that post‐transplant airway complications, including dehiscence and bronchial stenosis, would be more common in the short telomere ILD lung transplant population. Methods We conducted a multi‐institutional (Brigham and Women's Hospital, Groupe de Transplantation de la SPLF) retrospective cohort study of 63 recipients between 2009 and 2019 with ILD and short telomeres, compared to 4359 recipients from the Scientific Registry of Transplant Recipients with ILD and no known telomeropathy. Results In the short telomere cohort, six recipients (9.5%) developed dehiscence and nine recipients (14.3%) developed stenosis, compared to 60 (1.4%) and 149 (3.4%) in the control, respectively. After adjusting for age, sex, and bilaterality, the presence of short telomeres was associated with higher odds of dehiscence (odds ratio (OR) = 8.24, 95% confidence interval (CI) = 3.34 20.29, p 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14552