Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

• Published in: Annals of surgical oncology 2018-01, Vol.25 (1), p.179-187
• Main Authors: Passot, Guillaume, Kim, Bradford J., Glehen, Olivier, Mehran, Reza J., Kopetz, Scott E., Goere, Diane, Overman, Michael J., Pocard, Marc, Marchal, Frédéric, Conrad, Claudius, Aloia, Thomas A., Vauthey, Jean-Nicolas, Chun, Yun Shin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Cancer; Colorectal Cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Female; Genes, ras - genetics; Hepatectomy; Humans; Life Sciences; Liver; Liver Neoplasms - genetics; Liver Neoplasms - secondary; Liver Neoplasms - surgery; Lung Neoplasms - genetics; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Metastasectomy; Metastases; Metastasis; Middle Aged; Mutation; Oncology; Peritoneal Neoplasms - genetics; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - surgery; Peritoneum; Surgery; Surgical Oncology; Survival; Survival Rate; Young Adult
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-017-6141-7

Background RAS mutation status is an important prognostic factor after resection of liver metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after resection of lung (LuM) and peritoneal (PM) metastases from CRC is unknown. Methods Between 2005 and 2014, all consecutive patients with known RAS status who underwent potentially curative resection for LiM, LuM, or PM were evaluated. Results A total of 720 patients with known RAS status underwent resection of LiM ( n  = 468), LuM ( n  = 102), and PM ( n  = 150). RAS mutations were identified in 63 and 58% of patients with LuM and PM, respectively, compared with 41% of patients with LiM ( p