REVIEW: Evidence supporting the ‘preparation for oxidative stress’ (POS) strategy in animals in their natural environment

• Published in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2024-07, Vol.293, p.111626-111626, Article 111626
• Main Authors: Giraud-Billoud, Maximiliano, Moreira, Daniel C., Minari, Marina, Andreyeva, Aleksandra, Campos, Élida G., Carvajalino-Fernández, Juan M., Istomina, Aleksandra, Michaelidis, Basile, Niu, Cuijuan, Niu, Yonggang, Ondei, Luciana, Prokić, Marko, Rivera-Ingraham, Georgina A., Sahoo, Debadas, Staikou, Alexandra, Storey, Janet M., Storey, Kenneth B., Vega, Israel A., Hermes-Lima, Marcelo
• Format: Article
• Language: English
• Subjects: Adaptation; Animals; Antioxidant defenses; Antioxidants - metabolism; Biodiversity and Ecology; Environment; Environmental Sciences; Environmental stress; Global Changes; Hypometabolism; Hypoxia - metabolism; Oxidative stress; Oxidative Stress - physiology; Oxygen; Reactive Nitrogen Species; Reactive Oxygen Species - metabolism
• ISSN: 1095-6433; 1531-4332
• DOI: 10.1016/j.cbpa.2024.111626

Hypometabolism is a common strategy employed by resilient species to withstand environmental stressors that would be life-threatening for other organisms. Under conditions such as hypoxia/anoxia, temperature and salinity stress, or seasonal changes (e.g. hibernation, estivation), stress-tolerant species down-regulate pathways to decrease energy expenditures until the return of less challenging conditions. However, it is with the return of these more favorable conditions and the reactivation of basal metabolic rates that a strong increase of reactive oxygen and nitrogen species (RONS) occurs, leading to oxidative stress. Over the last few decades, cases of species capable of enhancing antioxidant defenses during hypometabolic states have been reported across taxa and in response to a variety of stressors. Interpreted as an adaptive mechanism to counteract RONS formation during tissue hypometabolism and reactivation, this strategy was coined “Preparation for Oxidative Stress” (POS). Laboratory experiments have confirmed that over 100 species, spanning 9 animal phyla, apply this strategy to endure harsh environments. However, the challenge remains to confirm its occurrence in the natural environment and its wide applicability as a key survival element, through controlled experimentation in field and in natural conditions. Under such conditions, numerous confounding factors may complicate data interpretation, but this remains the only approach to provide an integrative look at the evolutionary aspects of ecophysiological adaptations. In this review, we provide an overview of representative cases where the POS strategy has been demonstrated among diverse species in natural environmental conditions, discussing the strengths and weaknesses of these results and conclusions. [Display omitted] •Many animals respond to hypoxia and other stresses by activating antioxidants.•This mechanism, preparation for oxidative stress (POS), happens in over 100 species.•Most POS-positive species were studied in laboratory-controlled experiments.•We describe in detail 15 species with the POS phenotype in the natural environment.•Only 32 animal species report POS in their natural habitat in literature.