Cell Count Analysis from Nonbronchoscopic Bronchoalveolar Lavage in Preterm Infants

To establish the reference values, diagnostic accuracy, and effect of various factors on cell count in intubated preterm neonates subjected to nonbronchoscopic bronchoalveolar lavage. This prospective, cross-sectional, blinded study included preterm neonates ventilated for any reason who underwent n...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 2018-09, Vol.200, p.30-37.e2
Main Authors: Dell'Orto, Valentina, Bourgeois-Nicolaos, Nadege, Rouard, Caroline, Romain, Olivier, Shankar-Aguilera, Shivani, Doucet-Populaire, Florence, De Luca, Daniele
Format: Article
Language:English
Subjects:
bronchoalveolar lavage
cellularity
Life Sciences
lung
neonate
prematurity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To establish the reference values, diagnostic accuracy, and effect of various factors on cell count in intubated preterm neonates subjected to nonbronchoscopic bronchoalveolar lavage. This prospective, cross-sectional, blinded study included preterm neonates ventilated for any reason who underwent nonbronchoscopic bronchoalveolar lavage if they had not previously received postnatal antibiotics or steroids. Lavage was performed before surfactant replacement, if any. A gentle ventilation policy was applied. Pneumonia was diagnosed using clinical criteria, without considering cell count. Investigators performing cell counts were blinded to the clinical data. There were 276 neonates enrolled; 36 had congenital or ventilator-associated pneumonia. In the 240 noninfected babies, median neutrophil count increased significantly after the first 2 days of ventilation (day 1, 2 cells per field [IQR, 0.0-9.5 cells per field]; day 2, 2 cells per field [IQR, 0-15 cells per field]; day 3, 20 cells per field [IQR, 2-99 cells per field]; day 4, 15 cells per field [IQR, 2-96 cells per field]; P 
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2018.04.074