Which magnetic resonance imaging feature is associated with treatment response in perianal fistulizing Crohn’s disease?

• Published in: Abdominal imaging 2024-08, Vol.49 (8), p.2913-2920
• Main Authors: Richard, Nicolas, Derinck, Antonin, Bridoux, Valérie, Charpentier, Cloé, Savoye Collet, Céline, Savoye, Guillaume
• Format: Article
• Language: English
• Subjects: Adult; Clinical outcomes; Crohn Disease - complications; Crohn Disease - diagnostic imaging; Crohn's disease; Female; Fibrosis; Fistulae; Gastroenterology; Health services; Hepatology; Humans; Imaging; Life Sciences; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Patients; Pelvis; Performance prediction; Radiology; Rectal Fistula - diagnostic imaging; Rectal Fistula - etiology; Retrospective Studies; Sensitivity and Specificity; Treatment Outcome
• ISSN: 2366-0058; 2366-004X; 2366-0058
• DOI: 10.1007/s00261-024-04238-3

Purpose Perianal fistulae are disabling complications of Crohn’s Disease. Magnetic resonance imaging features could predict treatment response. This study aimed to determine which magnetic resonance imaging features were predictive of long-term clinical outcome in real life. Methods Consecutive patients with magnetic resonance imaging performed in a tertiary center were retrospectively analyzed. Clinical outcome was defined as a need for surgical drainage of perianal fistulae or hospitalization. Clinical data and magnetic resonance imaging features (MAGNIFI-CD and Van Assche indices, degree of fibrosis) were studied. Results Fifty-two patients were included between 2016 and 2019 with a mean follow-up of 38 months [29;48]. A higher MAGNIFI-CD index (17/25 versus 11/25; p