Tumor size of hepatocellular carcinoma in noncirrhotic liver: A controversial predictive factor for outcome after resection

• Published in: European journal of surgical oncology 2012-12, Vol.38 (12), p.1189-1196
• Main Authors: Truant, S, Boleslawski, E, Duhamel, A, Bouras, A.-F, Louvet, A, Febvay, C, Leteurtre, E, Huet, G, Zerbib, P, Dharancy, S, Hebbar, M, Pruvot, F.-R
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - surgery; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Hepatectomy; Hepatocellular carcinoma; Humans; Life Sciences; Liver - pathology; Liver Neoplasms - diagnosis; Liver Neoplasms - surgery; Liver transplantation; Magnetic Resonance Imaging; Male; Middle Aged; Multidetector Computed Tomography; Neoplasm Recurrence, Local; Noncirrhotic liver; Organ Size; Predictive Value of Tests; Prognosis; Prognosis factors; Prospective Studies; Surgery; Young Adult
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2012.07.112

Abstract Background Hepatocellular carcinoma in noncirrhotic liver (NC-HCC) presents usually with large size, which is seen as a contraindication to liver transplantation (LT) or even resection. The objective of our single-center study was to identify prognostic factors following resection of large NC-HCCs and to subsequently devise a treatment strategy (including LT) in selected patients. Methods From 2000 to 2010, 89 patients who had hepatic resection for NC-HCC (large ≥8 cm in 52) were analyzed with regard to pathological findings, postoperative and long-term outcome. Results Five patients died postoperatively. After a mean follow-up of 35 ± 30 months, NC-HCC recurred in 36 patients (26/47 survivors in group 8 cm+, 10/37 in group 8 cm−; p  = 0.007). Five-year overall (OS) and disease-free survival (DFS) rates were significantly worse for group 8 cm+ (43.4% vs. 89.2% and 39.3% vs. 60.7% for group 8 cm−, p