Bone mineral density at extremely low weight in patients with anorexia nervosa

Objective Low bone mineral density (BMD) is a frequent and invalidating consequence of chronic undernourishment in patients with anorexia nervosa (AN). The aim of this study was to assess prevalence and clinic‐biological correlates of low BMD and fractures in extremely undernourished inpatients with...

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Published in:Clinical endocrinology (Oxford) 2021-09, Vol.95 (3), p.423-429
Main Authors: Bemer, Pauline, Di Lodovico, Laura, Haykanush, Ohanyan, Théodon, Hélène, Briot, Karine, Carlier, Robert, Dicembre, Marika, Duquesnoy, Maéva, Melchior, Jean‐Claude, Hanachi, Mouna
Format: Article
Language:English
Subjects:
Anorexia
anorexia nervosa
Bone density
Bone mineral density
Dual energy X-ray absorptiometry
Eating disorders
Femur
Fractures
Life Sciences
Malnutrition
Osteoporosis
Patients
sodium
Spine (lumbar)
Z‐score
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Summary:Objective Low bone mineral density (BMD) is a frequent and invalidating consequence of chronic undernourishment in patients with anorexia nervosa (AN). The aim of this study was to assess prevalence and clinic‐biological correlates of low BMD and fractures in extremely undernourished inpatients with AN. Design Retrospective cohort study. Patients and measurements This study included 97 extremely malnourished female inpatients with AN consecutively admitted over 2 years. Clinical‐biological variables, history of fractures and BMD by dual‐energy X‐ray absorptiometry (DXA) were examined to find predictors of low BMD and fractures. Results The prevalence of low BMD was of 51% for lumbar spine and 38% for femoral neck. Z‐scores were lower at lumbar spine (−2.2 ± 1.2 SD) than at femoral neck (−1.9 ± 0.9 SD) (P
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14498