The Design of RNA Binders: Targeting the HIV Replication Cycle as a Case Study

The human immunodeficiency virus 1 (HIV‐1) replication cycle is finely tuned with many important steps involving RNA–RNA or protein–RNA interactions, all of them being potential targets for the development of new antiviral compounds. This cycle can also be considered as a good benchmark for the eval...

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Bibliographic Details
Published in:ChemMedChem 2014-09, Vol.9 (9), p.1982-1996
Main Authors: Blond, Aurélie, Ennifar, Eric, Tisné, Carine, Micouin, Laurent
Format: Article
Language:English
Subjects:
Animals
Anti-HIV Agents - pharmacology
antiviral agents
Antiviral Agents - pharmacology
Biochemistry, Molecular Biology
Drug Design
HIV
Human immunodeficiency virus
Human immunodeficiency virus 1
Humans
Life Sciences
Models, Molecular
new targets
RNA recognition
RNA, Viral - drug effects
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Summary:The human immunodeficiency virus 1 (HIV‐1) replication cycle is finely tuned with many important steps involving RNA–RNA or protein–RNA interactions, all of them being potential targets for the development of new antiviral compounds. This cycle can also be considered as a good benchmark for the evaluation of early‐stage strategies aiming at designing drugs that bind to RNA, with the possibility to correlate in vitro activities with antiviral properties. In this review, we highlight different approaches developed to interfere with four important steps of the HIV‐1 replication cycle: the early stage of reverse transcription, the transactivation of viral transcription, the nuclear export of partially spliced transcripts and the dimerization step. Interfering at the RNA level: The HIV‐1 replication cycle is finely tuned with many important steps involving RNA–RNA or protein–RNA interactions, all of them being potential targets for the development of new antiviral compounds. This review highlights approaches developed to interfere with four important steps of the HIV‐1 replication cycle.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201402259