Characterization of IMIC, an implantable needle-shaped positron sensitive monolithic active pixel sensor for preclinical molecular neuroimaging

The correlation of molecular neuroimaging and behavior studies in preclinical PET imaging is of major interest to unlock progress in the understanding of brain processes and assess the validity of preclinical studies in drug development. However, fully achieving this ambition requires performing mol...

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Published in:Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment Accelerators, spectrometers, detectors and associated equipment, 2024-07, Vol.1064, p.169456, Article 169456
Main Authors: El ketara, S., Agnese, F., Ammour, L., Bouvard, S., Clausse, O., Dupont, M., Gensolen, F., Goffe, M., Kachel, M., Laurence, J., Pangaud, P., Wabnitz, C., Weicherding, T., Baudot, J., Lanièce, P., Morel, C., Zimmer, L., Verdier, M.-A.
Format: Article
Language:English
Subjects:
Beta probe
CMOS image sensors
Instrumentation and Detectors
Molecular imaging
Monolithic active pixel sensors
Neuroimaging
Particle detection
Physics
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Summary:The correlation of molecular neuroimaging and behavior studies in preclinical PET imaging is of major interest to unlock progress in the understanding of brain processes and assess the validity of preclinical studies in drug development. However, fully achieving this ambition requires performing molecular images of awake and freely moving animals, whereas most of the preclinical imaging procedures are currently performed under anesthesia. To overcome this issue, the MAPSSIC project aims to develop a pixelated intracerebral probe to be implanted into awake and freely moving rats. The aforementioned probe relies on IMIC (Imageur Moléculaire Intra Cérébral), a Monolithic Active Pixel Sensor (MAPS) prototype set to directly detect positrons. The IMIC sensors were produced in 5 different configurations. Measurements using a 204Tl source showed that the sensor parameters can be optimized to boost its performance allowing to increase the sensitivity and reduce the average cluster size. In addition, comparisons between sensor configurations show a clear gain provided by the introduction of CMOS process modifications. Finally, the choice of the optimal sensor configuration will depend on the expected in vivo conditions.
ISSN:0168-9002
1872-9576
DOI:10.1016/j.nima.2024.169456